Bit of an odd one. Any new computers that I install 19.43 agent on for the first time then get blocked for remote access on the domain. Remote desktop still works but for example navigating to C$ doesn't, neither does the internal VNC.
This also blocks it from seeing WSUS or from my deployment software (PDQ) being able to deploy to it.
Further, it won't remove Webroot from the web panel, almost certainly related to the fact that the admin share can't be accessed.
Any systems that had 18.44 and then updated to 19.43 are fine.