I do not know what's different and it's not every update, but often when Opera updates and I go to run it I get this error message. The error message "fixes" were useless as it turns out Webroot is somehow blocking the program.
I have confirmed that Webroot is the offender as I can run Opera just fine when I shut down protection.
Best answer by SXR6
Michael here is old thread on an issue with Webroot and Opera.